Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer’s disease neurons

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disease of the brain and the most common form of dementia in the elderly. Aneuploidy, a state in which cells have an abnormal number of chromosomes, has been proposed to play a role in neurodegeneration in AD patients. Several studies using...

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發表在:Genome Biol
Main Authors: van den Bos, Hilda, Spierings, Diana C. J., Taudt, Aaron S., Bakker, Bjorn, Porubský, David, Falconer, Ester, Novoa, Carolina, Halsema, Nancy, Kazemier, Hinke G., Hoekstra-Wakker, Karina, Guryev, Victor, den Dunnen, Wilfred F. A., Foijer, Floris, Tatché, Maria Colomé, Boddeke, Hendrikus W. G. M., Lansdorp, Peter M.
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888403/
https://ncbi.nlm.nih.gov/pubmed/27246599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0976-2
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