Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies

BACKGROUND: Chromosome instability leads to aneuploidy, a state in which cells have abnormal numbers of chromosomes, and is found in two out of three cancers. In a chromosomal instable p53 deficient mouse model with accelerated lymphomagenesis, we previously observed whole chromosome copy number cha...

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發表在:Genome Biol
Main Authors: Bakker, Bjorn, Taudt, Aaron, Belderbos, Mirjam E., Porubsky, David, Spierings, Diana C. J., de Jong, Tristan V., Halsema, Nancy, Kazemier, Hinke G., Hoekstra-Wakker, Karina, Bradley, Allan, de Bont, Eveline S. J. M., van den Berg, Anke, Guryev, Victor, Lansdorp, Peter M., Colomé-Tatché, Maria, Foijer, Floris
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888588/
https://ncbi.nlm.nih.gov/pubmed/27246460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0971-7
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