Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this spectrum is its involvement in pain and inflammation. However, few small-molecule inhibitors of TRPV4 are available. Here we developed TRPV4-inh...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Kanju, Patrick, Chen, Yong, Lee, Whasil, Yeo, Michele, Lee, Suk Hee, Romac, Joelle, Shahid, Rafiq, Fan, Ping, Gooden, David M., Simon, Sidney A., Spasojevic, Ivan, Mook, Robert A., Liddle, Rodger A., Guilak, Farshid, Liedtke, Wolfgang B.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887995/
https://ncbi.nlm.nih.gov/pubmed/27247148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26894
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares