TRPM7 kinase activity regulates murine mast cell degranulation

KEY POINTS: The Mg(2+) and Ca(2+) conducting transient receptor potential melastatin 7 (TRPM7) channel–enzyme (chanzyme) has been implicated in immune cell function. Mice heterozygous for a TRPM7 kinase deletion are hyperallergic, while mice with a single point mutation at amino acid 1648, silencing...

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Detalles Bibliográficos
Publicado en:J Physiol
Main Authors: Zierler, Susanna, Sumoza‐Toledo, Adriana, Suzuki, Sayuri, Dúill, Fionán Ó, Ryazanova, Lillia V., Penner, Reinhold, Ryazanov, Alexey G., Fleig, Andrea
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Molecular and Cellular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887679/
https://ncbi.nlm.nih.gov/pubmed/26660477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271564
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