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Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action
Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated D2Rs (D2R-OE(dev) mice) are reversed by decreasing function...
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| Publié dans: | J Neurosci |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887564/ https://ncbi.nlm.nih.gov/pubmed/27251620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0444-16.2016 |
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