Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action

Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated D2Rs (D2R-OE(dev) mice) are reversed by decreasing function...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Carvalho Poyraz, Fernanda, Holzner, Eva, Bailey, Matthew R., Meszaros, Jozsef, Kenney, Lindsay, Kheirbek, Mazen A., Balsam, Peter D., Kellendonk, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887564/
https://ncbi.nlm.nih.gov/pubmed/27251620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0444-16.2016
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