In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agents

Novel imidazo[4,5-c]quinolin-2-ones were synthesized and evaluated in asexual blood stage and late stage gametocyte assays of Plasmodium falciparum, a major causative agent of malaria. The design of these compounds is based on a recently identified lead compound from a high throughput screen. A conc...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Patel, Paresma R., Sun, Wei, Kim, Myunghoon, Huang, Xiuli, Sanderson, Philip E., Tanaka, Takeshi Q., McKew, John C., Simeonov, Anton, Williamson, Kim C., Zheng, Wei, Huang, Wenwei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887403/
https://ncbi.nlm.nih.gov/pubmed/27156776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.04.045
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