Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1

SPLUNC1 is an abundantly secreted innate immune protein in the mammalian respiratory tract that exerts bacteriostatic and antibiofilm effects, binds to lipopolysaccharide (LPS), and acts as a fluid-spreading surfactant. Here, we unravel the structural elements essential for the surfactant and antimi...

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Detalles Bibliográficos
Publicado en:Biochemistry
Main Authors: Walton, William G., Ahmad, Saira, Little, Michael R., Kim, Christine S.K., Tyrrell, Jean, Lin, Qiao, Di, Y. Peter, Tarran, Robert, Redinbo, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887393/
https://ncbi.nlm.nih.gov/pubmed/27145151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00271
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