Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1

SPLUNC1 is an abundantly secreted innate immune protein in the mammalian respiratory tract that exerts bacteriostatic and antibiofilm effects, binds to lipopolysaccharide (LPS), and acts as a fluid-spreading surfactant. Here, we unravel the structural elements essential for the surfactant and antimi...

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Udgivet i:Biochemistry
Main Authors: Walton, William G., Ahmad, Saira, Little, Michael R., Kim, Christine S.K., Tyrrell, Jean, Lin, Qiao, Di, Y. Peter, Tarran, Robert, Redinbo, Matthew R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887393/
https://ncbi.nlm.nih.gov/pubmed/27145151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00271
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