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Monovar: single nucleotide variant detection in single cells
Current variant callers are not suitable for single-cell DNA sequencing (SCS) as they do not account for allelic dropout, false-positive errors, and coverage non-uniformity. We developed Monovar, a novel statistical method for detecting and genotyping single nucleotide variants in SCS data. Evaluati...
שמור ב:
| הוצא לאור ב: | Nat Methods |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887298/ https://ncbi.nlm.nih.gov/pubmed/27088313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3835 |
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