Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers

Neurofibromin 1–mutant (NF1-mutant) cancers are driven by excessive Ras signaling; however, there are currently no effective therapies for these or other Ras-dependent tumors. While combined MEK and mTORC1 suppression causes regression of NF1-deficient malignancies in animal models, the potential to...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lock, Rebecca, Ingraham, Rachel, Maertens, Ophélia, Miller, Abigail L., Weledji, Nelly, Legius, Eric, Konicek, Bruce M., Yan, Sau-Chi B., Graff, Jeremy R., Cichowski, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887164/
https://ncbi.nlm.nih.gov/pubmed/27159396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85183
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