CD19 CAR–T cells of defined CD4(+):CD8(+) composition in adult B cell ALL patients

BACKGROUND. T cells that have been modified to express a CD19-specific chimeric antigen receptor (CAR) have antitumor activity in B cell malignancies; however, identification of the factors that determine toxicity and efficacy of these T cells has been challenging in prior studies in which phenotypi...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Turtle, Cameron J., Hanafi, Laïla-Aïcha, Berger, Carolina, Gooley, Theodore A., Cherian, Sindhu, Hudecek, Michael, Sommermeyer, Daniel, Melville, Katherine, Pender, Barbara, Budiarto, Tanya M., Robinson, Emily, Steevens, Natalia N., Chaney, Colette, Soma, Lorinda, Chen, Xueyan, Yeung, Cecilia, Wood, Brent, Li, Daniel, Cao, Jianhong, Heimfeld, Shelly, Jensen, Michael C., Riddell, Stanley R., Maloney, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887159/
https://ncbi.nlm.nih.gov/pubmed/27111235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85309
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