Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

The molecular chaperone Hsp90 protects deregulated signaling proteins that are vital for tumor growth and survival. Tumors generally display sensitivity and selectivity toward Hsp90 inhibitors; however, the molecular mechanism underlying this phenotype remains undefined. We report that the mitotic c...

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Udgivet i:Cell Rep
Main Authors: Woodford, Mark R., Truman, Andrew W., Dunn, Diana M., Jensen, Sandra M., Cotran, Richard, Bullard, Renee, Abouelleil, Mourad, Beebe, Kristin, Wolfgeher, Donald, Wierzbicki, Sara, Post, Dawn E., Caza, Tiffany, Tsutsumi, Shinji, Panaretou, Barry, Kron, Stephen J., Trepel, Jane B., Landas, Steve, Prodromou, Chrisostomos, Shapiro, Oleg, Stetler-Stevenson, William G., Bourboulia, Dimitra, Neckers, Len, Bratslavsky, Gennady, Mollapour, Mehdi
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887101/
https://ncbi.nlm.nih.gov/pubmed/26804907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.084
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