Clonal Dynamics In Vivo of Virus Integration Sites of T Cells Expressing a Safety Switch

Safety switches are becoming relevant for the clinical translation of T-cell–based immunotherapies. In patients receiving an allogeneic hematopoietic stem cell transplant, the inducible caspase-9 gene (iC9) safety switch expressed by donor-derived T lymphocytes efficiently controls acute graft versu...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Chang, Edmund C, Liu, Hao, West, John A, Zhou, Xiaoou, Dakhova, Olga, Wheeler, David A, Heslop, Helen E, Brenner, Malcolm K, Dotti, Gianpietro
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886929/
https://ncbi.nlm.nih.gov/pubmed/26639404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.217
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