Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

MicroRNAs have an important role in bone homeostasis. However, the detailed mechanism of microRNA-mediated intercellular communication between bone cells remains elusive. Here, we report that osteoclasts secrete microRNA-enriched exosomes, by which miR-214 is transferred into osteoblasts to inhibit...

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Dades bibliogràfiques
Publicat a:Cell Discov
Autors principals: Sun, Weijia, Zhao, Chenyang, Li, Yuheng, Wang, Liang, Nie, Guangjun, Peng, Jiang, Wang, Aiyuan, Zhang, Pengfei, Tian, Weiming, Li, Qi, Song, Jinping, Wang, Cheng, Xu, Xiaolong, Tian, Yanhua, Zhao, Dingsheng, Xu, Zi, Zhong, Guohui, Han, Bingxing, Ling, Shukuan, Chang, Yan-Zhong, Li, Yingxian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886818/
https://ncbi.nlm.nih.gov/pubmed/27462462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.15
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