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TMCO1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling
Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca(2+) leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of TMCO1 in osteogenesis me...
Shranjeno v:
| izdano v: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6453895/ https://ncbi.nlm.nih.gov/pubmed/30962442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09653-5 |
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