Wird geladen...

Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

Growing evidence supports a role for IL-1 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), but how it impacts neuroinflammation is poorly understood. We show that susceptibility to EAE requires activation of IL-1R1 on radiation-resistant cells via IL-1β secreted by bone mar...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Exp Med
Hauptverfasser: Lévesque, Sébastien A., Paré, Alexandre, Mailhot, Benoit, Bellver-Landete, Victor, Kébir, Hania, Lécuyer, Marc-André, Alvarez, Jorge Ivan, Prat, Alexandre, Vaccari, Juan Pablo de Rivero, Keane, Robert W., Lacroix, Steve
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886360/
https://ncbi.nlm.nih.gov/pubmed/27139491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151437
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!