Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

Growing evidence supports a role for IL-1 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), but how it impacts neuroinflammation is poorly understood. We show that susceptibility to EAE requires activation of IL-1R1 on radiation-resistant cells via IL-1β secreted by bone mar...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Lévesque, Sébastien A., Paré, Alexandre, Mailhot, Benoit, Bellver-Landete, Victor, Kébir, Hania, Lécuyer, Marc-André, Alvarez, Jorge Ivan, Prat, Alexandre, Vaccari, Juan Pablo de Rivero, Keane, Robert W., Lacroix, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886360/
https://ncbi.nlm.nih.gov/pubmed/27139491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151437
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