ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT

The crizotinib-resistant ALK(F1174L) mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel anaplastic lymphoma kinase (ALK) inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivat...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Debruyne, D N, Bhatnagar, N, Sharma, B, Luther, W, Moore, N F, Cheung, N-K, Gray, N S, George, R E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885798/
https://ncbi.nlm.nih.gov/pubmed/26616860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.434
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