Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation

Activation of G(s)-coupled receptors enhances engraftment of hematopoietic stem and progenitor cells (HSPCs). We tested the hypothesis that treprostinil, a prostacyclin analog approved for the treatment of pulmonary hypertension, can be repurposed to improve hematopoietic stem cell transplantation....

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Pubblicato in:Mol Pharmacol
Autori principali: Kazemi, Zahra, Bergmayr, Christian, Prchal-Murphy, Michaela, Javaheri, Tahereh, Themanns, Madeleine, Pham, Ha T. T., Strohmaier, Wolfgang, Sexl, Veronika, Freissmuth, Michael, Zebedin-Brandl, Eva
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885501/
https://ncbi.nlm.nih.gov/pubmed/26989084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.103267
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