RAD51 Variant Proteins from Human Lung and Kidney Tumors Exhibit DNA Strand Exchange Defects

In human cells, error-free repair of DNA double-strand breaks requires the DNA pairing and strand exchange activities of RAD51 recombinase. Activation of RAD51 recombination activities requires the assembly of RAD51 presynaptic filaments on the single-stranded DNA that forms at resected DSB ends. Mu...

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Gepubliceerd in:DNA Repair (Amst)
Hoofdauteurs: Silva, Michelle C., Morrical, Milagros D., Bryan, Katie E., Averill, April M., Dragon, Julie, Bond, Jeffrey P., Morrical, Scott W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884548/
https://ncbi.nlm.nih.gov/pubmed/27153211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.02.008
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