Resolution of specific nucleotide mismatches by wild type and AZT-resistant reverse transcriptases during HIV-1 replication

A key contributor to HIV-1 genetic variation is reverse transcriptase errors. Some mutations result because reverse transcriptase (RT) lacks 3′ to 5′ proofreading exonuclease and can extend mismatches. However, RT also excises terminal nucleotides to a limited extent, and this activity contributes t...

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Publicat a:J Mol Biol
Autors principals: Kharytonchyk, Siarhei, King, Steven R., Ndongmo, Clement B., Stilger, Krista L., An, Wenfeng, Telesnitsky, Alice
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884515/
https://ncbi.nlm.nih.gov/pubmed/27075671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.04.005
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