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Attenuation of morphine tolerance and dependence by thymoquinone in mice

OBJECTIVE: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. MATERIALS AND METHODS: Male ad...

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Bibliografische gegevens
Gepubliceerd in:Avicenna J Phytomed
Hoofdauteurs: Hosseinzadeh, Hossein, Parvardeh, Siavash, Masoudi, Alireza, Moghimi, Mahsa, Mahboobifard, Fatemeh
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mashhad University of Medical Sciences 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884218/
https://ncbi.nlm.nih.gov/pubmed/27247922
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