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Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis
Deficiency of the antiaging gene Klotho (KL) induces renal damage and hypertension through unknown mechanisms. In this study, we assessed whether KL regulates expression of CYP11B2, a key rate–limiting enzyme in aldosterone synthesis, in adrenal glands. We found that haplodeficiency of KL(+/−) in mi...
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| Udgivet i: | J Am Soc Nephrol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Nephrology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4884100/ https://ncbi.nlm.nih.gov/pubmed/26471128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015010093 |
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