High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells

Aldosterone synthase is the key rate‐limiting enzyme in adrenal aldosterone production, and induction of its gene (CYP11B2) results in the progression of hypertension. As hypertension is a frequent complication among patients with diabetes, we set out to elucidate the link between diabetes mellitus...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Shimada, Hiroki, Kogure, Naotaka, Noro, Erika, Kudo, Masataka, Sugawara, Kaori, Sato, Ikuko, Shimizu, Kyoko, Kobayashi, Makoto, Suzuki, Dai, Parvin, Rehana, Saito‐Ito, Takako, Uruno, Akira, Saito‐Hakoda, Akiko, Rainey, William E., Ito, Sadayoshi, Yokoyama, Atsushi, Sugawara, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586344/
https://ncbi.nlm.nih.gov/pubmed/28904869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12277
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