Apoptosis-associated speck-like protein containing CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

Apoptosis-associated speck-like protein containing a CARD (ASC) is a key adaptor molecule required for inflammatory processes. ASC acts by bridging NLRP proteins, such as NLRP3, with pro-caspase-1 within the inflammasome complex that subsequently results in the activation of caspase-1 and the secret...

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Publicado no:J Immunol
Main Authors: Compan, Vincent, Martín-Sánchez, Fátima, Baroja-Mazo, Alberto, López-Castejón, Gloria, Gomez, Ana I., Verkhratsky, Alexei, Brough, David, Pelegrín, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883655/
https://ncbi.nlm.nih.gov/pubmed/25552542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301676
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