Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

Deoxynucleotide triphosphates (dNTPs) are essential for efficient hepatitis B virus (HBV) replication. Here, we investigated the influence of the restriction factor SAMHD1, a dNTP hydrolase (dNTPase) and RNase, on HBV replication. We demonstrated that silencing of SAMHD1 in hepatic cells increased H...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Sommer, Andreas F. R., Rivière, Lise, Qu, Bingqian, Schott, Kerstin, Riess, Maximilian, Ni, Yi, Shepard, Caitlin, Schnellbächer, Esther, Finkernagel, Malin, Himmelsbach, Kiyoshi, Welzel, Karin, Kettern, Nadja, Donnerhak, Christian, Münk, Carsten, Flory, Egbert, Liese, Juliane, Kim, Baek, Urban, Stephan, König, Renate
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882586/
https://ncbi.nlm.nih.gov/pubmed/27229711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26616
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