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Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a
SAMHD1 is a phosphohydrolase maintaining cellular dNTP homeostasis but also acts as a critical regulator in innate immune responses due to its antiviral activity and association with autoimmune disease, leading to aberrant activation of interferon. SAMHD1 expression is differentially regulated by in...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5217685/ https://ncbi.nlm.nih.gov/pubmed/27909056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752584 |
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