Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

Deoxynucleotide triphosphates (dNTPs) are essential for efficient hepatitis B virus (HBV) replication. Here, we investigated the influence of the restriction factor SAMHD1, a dNTP hydrolase (dNTPase) and RNase, on HBV replication. We demonstrated that silencing of SAMHD1 in hepatic cells increased H...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Sommer, Andreas F. R., Rivière, Lise, Qu, Bingqian, Schott, Kerstin, Riess, Maximilian, Ni, Yi, Shepard, Caitlin, Schnellbächer, Esther, Finkernagel, Malin, Himmelsbach, Kiyoshi, Welzel, Karin, Kettern, Nadja, Donnerhak, Christian, Münk, Carsten, Flory, Egbert, Liese, Juliane, Kim, Baek, Urban, Stephan, König, Renate
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882586/
https://ncbi.nlm.nih.gov/pubmed/27229711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26616
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