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Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents
A conformational restriction strategy was used to design and synthesize nine TZT-1027 analogues. 3-Aryl-azetidine moiety was used to replace phenylethyl group of TZT-1027 at the C-terminus. These analogues exhibited moderate to excellent antiproliferative activities, and the most potent compound 1a...
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| Udgivet i: | Mar Drugs |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882559/ https://ncbi.nlm.nih.gov/pubmed/27136567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14050085 |
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