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Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents

A conformational restriction strategy was used to design and synthesize nine TZT-1027 analogues. 3-Aryl-azetidine moiety was used to replace phenylethyl group of TZT-1027 at the C-terminus. These analogues exhibited moderate to excellent antiproliferative activities, and the most potent compound 1a...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mar Drugs
मुख्य लेखकों: Yan, Qi, Wang, Yujie, Zhang, Wei, Li, Yingxia
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882559/
https://ncbi.nlm.nih.gov/pubmed/27136567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14050085
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