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Inhibition of fatty acid synthase is protective in pulmonary hypertension

BACKGROUND AND PURPOSE: In pulmonary hypertension (PH), similar to cancer, there is altered energy metabolism, apoptosis resistance and cellular proliferation leading to pulmonary vascular remodelling. Proliferating cells exhibit higher rate of de novo fatty acid synthesis to provide lipids for memb...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Singh, Neetu, Manhas, Amit, Kaur, Gurpreet, Jagavelu, Kumaravelu, Hanif, Kashif
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882492/
https://ncbi.nlm.nih.gov/pubmed/27061087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13495
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