The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFI(m)) Complex Mediates HIV-1 Integration into Genes

HIV-1 favors integration into active genes and gene-enriched regions of host cell chromosomes, thus maximizing the probability of provirus expression immediately after integration. This requires cleavage and polyadenylation specificity factor 6 (CPSF6), a cellular protein involved in pre-mRNA 3′ end...

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Vydáno v:J Biol Chem
Hlavní autoři: Rasheedi, Sheeba, Shun, Ming-Chieh, Serrao, Erik, Sowd, Gregory A., Qian, Juan, Hao, Caili, Dasgupta, Twishasri, Engelman, Alan N., Skowronski, Jacek
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882448/
https://ncbi.nlm.nih.gov/pubmed/26994143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.721647
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