Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIMETABOLITES

Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T. brucei cultivated in the presence of deoxyadenosine accumulates high levels of dATP in an adenosine kinase-dependent process...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Vodnala, Munender, Ranjbarian, Farahnaz, Pavlova, Anna, de Koning, Harry P., Hofer, Anders
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882440/
https://ncbi.nlm.nih.gov/pubmed/27036940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715615
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