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Impact of UGT2B17 Gene Deletion on the Pharmacokinetics of 17-hydroexemestane in Healthy Volunteers
Exemestane is an aromatase inhibitor drug used for the treatment of hormone-dependent breast cancer. 17-hydroexemestane, the major and biologically active metabolite of exemestane in humans is eliminated via glucuronidation by the polymorphic UGT2B17 phase II drug metabolizing enzyme. Previous micro...
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| Publicado no: | J Clin Pharmacol |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882280/ https://ncbi.nlm.nih.gov/pubmed/26608382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.673 |
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