Characterizing strain variation in engineered E. coli using a multi-omics based workflow

Understanding the complex interactions that occur between heterologous and native biochemical pathways represents a major challenge in metabolic engineering and synthetic biology. We present a workflow that integrates metabolomics, proteomics, and genome-scale models of Escherichia coli metabolism t...

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Gepubliceerd in:Cell Syst
Hoofdauteurs: Brunk, Elizabeth, George, Kevin W., Alonso-Gutierrez, Jorge, Thompson, Mitchell, Baidoo, Edward, Wang, George, Petzold, Christopher J., McCloskey, Douglas, Monk, Jonathan, Yang, Laurence, O’Brien, Edward J., Batth, Tanveer S., Martin, Hector Garcia, Feist, Adam, Adams, Paul D., Keasling, Jay D., Palsson, Bernhard O., Lee, Taek Soon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882250/
https://ncbi.nlm.nih.gov/pubmed/27211860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.04.004
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