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Characterizing strain variation in engineered E. coli using a multi-omics based workflow

Understanding the complex interactions that occur between heterologous and native biochemical pathways represents a major challenge in metabolic engineering and synthetic biology. We present a workflow that integrates metabolomics, proteomics, and genome-scale models of Escherichia coli metabolism t...

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Publicado en:Cell Syst
Autores principales: Brunk, Elizabeth, George, Kevin W., Alonso-Gutierrez, Jorge, Thompson, Mitchell, Baidoo, Edward, Wang, George, Petzold, Christopher J., McCloskey, Douglas, Monk, Jonathan, Yang, Laurence, O’Brien, Edward J., Batth, Tanveer S., Martin, Hector Garcia, Feist, Adam, Adams, Paul D., Keasling, Jay D., Palsson, Bernhard O., Lee, Taek Soon
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882250/
https://ncbi.nlm.nih.gov/pubmed/27211860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.04.004
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