Characterizing strain variation in engineered E. coli using a multi-omics based workflow

Understanding the complex interactions that occur between heterologous and native biochemical pathways represents a major challenge in metabolic engineering and synthetic biology. We present a workflow that integrates metabolomics, proteomics, and genome-scale models of Escherichia coli metabolism t...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Brunk, Elizabeth, George, Kevin W., Alonso-Gutierrez, Jorge, Thompson, Mitchell, Baidoo, Edward, Wang, George, Petzold, Christopher J., McCloskey, Douglas, Monk, Jonathan, Yang, Laurence, O’Brien, Edward J., Batth, Tanveer S., Martin, Hector Garcia, Feist, Adam, Adams, Paul D., Keasling, Jay D., Palsson, Bernhard O., Lee, Taek Soon
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882250/
https://ncbi.nlm.nih.gov/pubmed/27211860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.04.004
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