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Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-based Scaffold with a Pyridine Linker

Neuronal nitric oxide synthase (nNOS) is an important therapeutic target for the treatment of various neurodegenerative disorders. A major challenge in the design of nNOS inhibitors focuses on potency in humans and selectivity over other NOS isoforms. Here we report potent and selective human nNOS i...

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Dades bibliogràfiques
Publicat a:J Med Chem
Autors principals: Wang, Heng-Yen, Qin, Yajuan, Li, Huiying, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882237/
https://ncbi.nlm.nih.gov/pubmed/27050842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00273
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