Impaired Corpus Cavernosum Relaxation Is Accompanied by Increased Oxidative Stress and Up-Regulation of the Rho-Kinase Pathway in Diabetic (Db/Db) Mice

Basal release of nitric oxide from endothelial cells modulates contractile activity in the corpus cavernosum via inhibition of the RhoA/Rho-kinase signaling pathway. We aimed to investigate nitric oxide bioavailability, oxidative stress and the Rho-kinase pathway in the relaxation of the corpus cave...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Priviero, Fernanda B. M., Toque, Haroldo A. F., Nunes, Kenia Pedrosa, Priolli, Denise G., Teixeira, Cleber E., Webb, R. Clinton
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882003/
https://ncbi.nlm.nih.gov/pubmed/27227463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156030
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