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RhoA/Rho-kinase and vascular diseases: what is the link?

RhoA/Rho-kinase pathway plays an important role in many pathological conditions. RhoA participates in the regulation of smooth muscle tone and activates many downstream kinases. The best characterized are the serine/threonine kinase isoforms (Rho-kinase or ROCK), ROCKα/ROCK2 and ROCKβ/ROCK1. ROCK is...

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Autori principali: Nunes, Kenia Pedrosa, Rigsby, Christine S., Webb, R. Clinton
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996825/
https://ncbi.nlm.nih.gov/pubmed/20668910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0460-1
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