Targeted Polymeric Nanoparticles for Brain Delivery of High Molecular Weight Molecules in Lysosomal Storage Disorders

Lysosomal Storage Disorders (LSDs) are a group of metabolic syndromes, each one due to the deficit of one lysosomal enzyme. Many LSDs affect most of the organ systems and overall about 75% of the patients present neurological impairment. Enzyme Replacement Therapy, although determining some systemic...

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Veröffentlicht in:PLoS One
Hauptverfasser: Salvalaio, Marika, Rigon, Laura, Belletti, Daniela, D’Avanzo, Francesca, Pederzoli, Francesca, Ruozi, Barbara, Marin, Oriano, Vandelli, Maria Angela, Forni, Flavio, Scarpa, Maurizio, Tomanin, Rosella, Tosi, Giovanni
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881964/
https://ncbi.nlm.nih.gov/pubmed/27228099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156452
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