Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8

A detrimental role for matrix metalloproteinase 8 (MMP8) has been identified in several pathological conditions, e.g., lethal hepatitis and the systemic inflammatory response syndrome. Since matrix MMP8-deficient mice are protected in the above-mentioned diseases, specific MMP8 inhibitors could be o...

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Publicado en:Mol Ther
Autores principales: Demeestere, Delphine, Dejonckheere, Eline, Steeland, Sophie, Hulpiau, Paco, Haustraete, Jurgen, Devoogdt, Nick, Wichert, Rielana, Becker-Pauly, Christoph, Van Wonterghem, Elien, Dewaele, Sylviane, Van Imschoot, Griet, Aerts, Jeroen, Arckens, Lutgarde, Saeys, Yvan, Libert, Claude, Vandenbroucke, Roosmarijn E
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881768/
https://ncbi.nlm.nih.gov/pubmed/26775809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.2
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