Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1

The cytokine TNF is a well known drug target for several inflammatory diseases such as Crohn disease. Despite the great success of TNF blockers, therapy could be improved because of high costs and side effects. Selective inhibition of TNF receptor (TNFR) 1 signaling holds the potential to greatly re...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Steeland, Sophie, Puimège, Leen, Vandenbroucke, Roosmarijn E., Van Hauwermeiren, Filip, Haustraete, Jurgen, Devoogdt, Nick, Hulpiau, Paco, Leroux-Roels, Geert, Laukens, Debby, Meuleman, Philip, De Vos, Martine, Libert, Claude
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326813/
https://ncbi.nlm.nih.gov/pubmed/25538244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617787
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