Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1

The cytokine TNF is a well known drug target for several inflammatory diseases such as Crohn disease. Despite the great success of TNF blockers, therapy could be improved because of high costs and side effects. Selective inhibition of TNF receptor (TNFR) 1 signaling holds the potential to greatly re...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Steeland, Sophie, Puimège, Leen, Vandenbroucke, Roosmarijn E., Van Hauwermeiren, Filip, Haustraete, Jurgen, Devoogdt, Nick, Hulpiau, Paco, Leroux-Roels, Geert, Laukens, Debby, Meuleman, Philip, De Vos, Martine, Libert, Claude
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326813/
https://ncbi.nlm.nih.gov/pubmed/25538244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617787
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