Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing

Recent successful clinical trials with recombinant adeno-associated viral vectors (rAAVs) have led to a renewed interest in gene therapy. However, despite extensive developments to improve vector-manufacturing processes, undesirable DNA contaminants in rAAV preparations remain a major safety concern...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Lecomte, Emilie, Tournaire, Benoît, Cogné, Benjamin, Dupont, Jean-Baptiste, Lindenbaum, Pierre, Martin-Fontaine, Mélanie, Broucque, Frédéric, Robin, Cécile, Hebben, Matthias, Merten, Otto-Wilhelm, Blouin, Véronique, François, Achille, Redon, Richard, Moullier, Philippe, Léger, Adrien
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
Soggetti:
Methods: Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881760/
https://ncbi.nlm.nih.gov/pubmed/26506038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.32
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi