Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing

Recent successful clinical trials with recombinant adeno-associated viral vectors (rAAVs) have led to a renewed interest in gene therapy. However, despite extensive developments to improve vector-manufacturing processes, undesirable DNA contaminants in rAAV preparations remain a major safety concern...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Lecomte, Emilie, Tournaire, Benoît, Cogné, Benjamin, Dupont, Jean-Baptiste, Lindenbaum, Pierre, Martin-Fontaine, Mélanie, Broucque, Frédéric, Robin, Cécile, Hebben, Matthias, Merten, Otto-Wilhelm, Blouin, Véronique, François, Achille, Redon, Richard, Moullier, Philippe, Léger, Adrien
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Methods: Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881760/
https://ncbi.nlm.nih.gov/pubmed/26506038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.32
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