Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling

Integrated stress responses (ISR) may lead to cell death and tissue degeneration via eukaryotic translation initiation factor 2 α (eIF2α)-mediated signaling. Alleviating ISR by modulating eIF2α phosphorylation can reduce the symptoms associated with various diseases. Guanabenz is known to elevate th...

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Udgivet i:Int J Mol Sci
Main Authors: Takigawa, Shinya, Chen, Andy, Nishimura, Akinobu, Liu, Shengzhi, Li, Bai-Yan, Sudo, Akihiro, Yokota, Hiroki, Hamamura, Kazunori
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881500/
https://ncbi.nlm.nih.gov/pubmed/27164082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17050674
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