Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma

Glycine N-methyltransferase (GNMT) expression is vastly downregulated in hepatocellular carcinomas (HCC). High rates of GNMT knockout mice developed HCC, while overexpression of GNMT prevented aflatoxin-induced carcinogenicity and inhibited liver cancer cell proliferation. Therefore, in this study,...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Kant, Rajni, Yen, Chia-Hung, Lu, Chung-Kuang, Lin, Ying-Chi, Li, Jih-Heng, Chen, Yi-Ming Arthur
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881495/
https://ncbi.nlm.nih.gov/pubmed/27153064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17050669
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