TREX1 knockdown induces an interferon response to HIV that delays viral infection in humanized mice

Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection. HIV does not normally induce Type I interferons in infected cells, but does if TREX1 is knocked do...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wheeler, Lee Adam, Trifonova, Radiana T., Vrbanac, Vladimir, Barteneva, Natasha S., Liu, Xing, Bollman, Brooke, Onofrey, Lauren, Mulik, Sachin, Ranjbar, Shahin, Luster, Andrew D., Tager, Andrew M., Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881429/
https://ncbi.nlm.nih.gov/pubmed/27184854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.048
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