Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

The continued spread of the HIV epidemic underscores the need to interrupt transmission. One attractive strategy is a topical vaginal microbicide. Sexual transmission of herpes simplex virus type 2 (HSV-2) in mice can be inhibited by intravaginal siRNA application. To overcome the challenges of knoc...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wheeler, Lee Adam, Trifonova, Radiana, Vrbanac, Vladimir, Basar, Emre, McKernan, Shannon, Xu, Zhan, Seung, Edward, Deruaz, Maud, Dudek, Tim, Einarsson, Jon Ivar, Yang, Linda, Allen, Todd M., Luster, Andrew D., Tager, Andrew M., Dykxhoorn, Derek M., Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104760/
https://ncbi.nlm.nih.gov/pubmed/21576818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45876
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados