Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

The continued spread of the HIV epidemic underscores the need to interrupt transmission. One attractive strategy is a topical vaginal microbicide. Sexual transmission of herpes simplex virus type 2 (HSV-2) in mice can be inhibited by intravaginal siRNA application. To overcome the challenges of knoc...

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書誌詳細
主要な著者: Wheeler, Lee Adam, Trifonova, Radiana, Vrbanac, Vladimir, Basar, Emre, McKernan, Shannon, Xu, Zhan, Seung, Edward, Deruaz, Maud, Dudek, Tim, Einarsson, Jon Ivar, Yang, Linda, Allen, Todd M., Luster, Andrew D., Tager, Andrew M., Dykxhoorn, Derek M., Lieberman, Judy
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2011
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104760/
https://ncbi.nlm.nih.gov/pubmed/21576818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45876
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